Eperisone – An Antispasmodic – Centrally Acting Muscle Relaxant

Introduction
Eperisone (eperisone hydrochloride salt) available under brand name Myonal, Karisona, is an antispasmodic medication. Eperisone works by relaxing both skeletal and vascular smooth muscles, and it has a wide range of effects, including decreased myotonia, improved circulation, and suppression of the pain reflex.

Class of Medicine
Eperisone (eperisone hydrochloride salt) is a centrally acting muscle relaxant an Antispasmodic class of medicine. Eperisone works by relaxing both skeletal and vascular smooth muscles, and it has a wide range of effects, including decreased myotonia, improved circulation, and suppression of the pain reflex.

Mode of Action
The centrally acting muscle relaxant eperisone hydrochloride has showed potential in the treatment of pain. It works by inhibiting the voltage-gated sodium channels (VGSC) in the brain stem, which inhibits neuronal activity and pain feeling.

How should this medicine be used?
Eperisone comes in tablet form and can be taken orally 50 mg twice a day. Dosage should be adjusted based on age and symptoms. It’s best if you take it with food.
The treatment will last 14 days in total. Patients will be screened for baseline parameters before being randomly assigned to one of two groups, according to a preset randomization schedule. For a period of 14 days, patients will be given either Eperisone-HCl (Myonal) or placebo.

Common Side Effects

Eperisone is not recommended for people who have a history of hypersensitivity to the medicine.
Common side effects includes:

• Excessive relaxation
• Stomachache
• Nausea
• Vertigo
• Anorexia
• Sleepiness
• Skin rashes
• Diarrhoea
• Vomiting
• Indigestion
• GI troubles
• Insomnia
• Headache
• Constipation
• other side effects are “very infrequent.”

Important Warning

When Eperisone is taken with 1,2-Benzodiazepine, the risk of or severity of undesirable effects can rise.
When Eperisone is coupled with Abametapir, the serum levels of Eperisone can rise.
When Eperisone and Acarbose are combined, the risk or severity of hypoglycemia can be enhanced.
When Eperisone is taken in combination with Acemetacin, the risk of hyperkalemia is enhanced.
When Acetazolamide and Eperisone are combined, the risk of or severity of undesirable effects can be enhanced.
When Eperisone is coupled with Acetohexamide, the risk or severity of hypoglycemia may be enhanced.

Available Brands (list can be updated in future)
Myonal
Karisona