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Co-amoxiclav – A Penicillin Antibiotic


Co-amoxiclav is an antibiotic available under brand names of Augmentin, Calamox, Amoxi-Clave that is used to treat bacterial infections.

It is made composed of amoxicillin (a penicillin antibiotic) and clavulanic acid. The clavulanic acid in amoxicillin prevents bacteria from breaking it down, allowing the antibiotic to operate more effectively.

Class of Medicine
Co-amoxiclav is an antibiotic that acts by killing infection-causing bacteria. It comprises amoxicillin and clavulanic acid, which are two distinct antibiotics. Amoxicillin is part of a class of antibiotics known as “penicillins.”

Mode of Action
Amoxicillin belongs to a group of antibiotics known as penicillin-like drugs. It works by preventing bacteria from growing. Clavulanic acid belongs to the beta-lactamase inhibitors class of drugs. It works by preventing amoxicillin from being destroyed by bacteria.
Amoxicillin and clavulanic acid are combined in this antibiotic. It kills germs by preventing them from forming cell walls. – Clavulanic acid inhibits the chemical defence against penicillins known as beta-lactamase, which is found in some bacteria.

How should this medicine be used?
Amoxicillin with clavulanic acid is available as a tablet, a chewable tablet, an extended-release (long-acting) tablet, and a solution (liquid) for oral administration. Every 8 hours (three times a day) or every 12 hours, the pills, chewable tablets, and suspension are commonly taken at the start of a meal (twice a day). The extended-release tablets are normally taken every 12 hours with a meal or snack (twice a day). Take amoxicillin and clavulanate at the same times every day to make it easier to remember. Follow the directions on your prescription label carefully, and if there is anything you don’t understand, ask your doctor or pharmacist to explain it to you.

Follow the directions for taking amoxicillin and clavulanic acid strictly. Do not take more or less of it, or take it more frequently than your doctor has suggested.

Common Side Effects
upset stomach
mild skin

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
severe skin rash
difficulty breathing or swallowing
vaginal itching and discharge
yellowing of the skin or eyes rash

Important Warning

People with phenylketonuria, a rare genetic disorder, should avoid taking co-amoxiclav liquid.

If you have this disease, the beverage may include aspartame, which might be dangerous.

Co-amoxiclav does not combine well with a number of medications.

Before starting co-amoxiclav, tell your doctor if you’re taking any of the following medications:

  • Allopurinol or probenecid, which are used to treat gout
  • Warfarin, a blood thinner
  • Methotrexate, a cancer or rheumatic disease treatment
  • Mycophenolate mofetil is a drug that is used to keep transplanted organs from being rejected.

Available Brands (list can be updated in future)

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Thiocolchicoside – An Analgesic and Anti-inflammatory

Thiocolchicoside is a semi-synthetic colchicine derivative used as an analgesic and anti-inflammatory.
Muscoril, Thiolax, and Myolax are all examples of thiocolchicoside, a muscle relaxant with anti-inflammatory and analgesic properties. It is a competitive GABAA receptor antagonist, as well as a potent glycine receptor antagonist and a weaker nicotinic acetylcholine receptor antagonist.

* It has strong convulsant properties and should not be used by people who are prone to seizures.

Class of Medicine
Colchicine is a natural anti-inflammatory glycoside derived from the flower seeds of Superba gloriosa. Thiocolchicoside is a semi-synthetic derivative of colchicine. It’s a muscle relaxant with analgesic and anti-inflammatory properties.

Mode of Action

Thiocholchicoside is a muscle relaxant that operates by binding to the GABA-A receptor selectively. It works by stimulating the GABA inhibitory motor pathway, which stops muscle contractions.

This medicine inhibits glycine receptors with the same efficacy as nicotinic acetylcholine receptors and functions as a competitive GABA receptor antagonist. It has strong convulsant properties and should not be used in people who are prone to seizures.

Patients having hysterosalpingography are sedated with this drug in combination with glafenine and meprobamate. It is used to relieve painful muscle spasms. Thiocolchicoside works in reflex, rheumatic, and traumatic contractures as well as contractures with a central aetiology. It also helps with spastic hemiparesis sequelae, Parkinson’s disease, and iatrogenic Parkinson symptoms, such as neurodyslectic syndrome. Acute and chronic lumbar and sciatic pain, cervico-brachial neuralgia, persistent torticollis, and post-traumatic and post-operative pain are some of the additional disorders that may benefit from this medicine.

How should this medicine be used?
Thiocolchicoside is a muscle relaxant used to treat back pain and other aches caused by diseases of the vertebral column or spinal cord, as well as to relieve pain following surgery. This drug works by interacting with particular receptors in the brain and spinal cord.

The highest suggested oral dose is 8 mg per 12 hours, with a maximum treatment period of 7 days. The highest dose taken intramuscularly (IM) is 4 mg every 12 hours for a maximum of 5 days 14. A study was conducted on the hepatotoxic potential of thiocolchicoside in addition to the aforesaid toxicity.

Common Side Effects
Skin rash
Swelling of face
Yellowing of skin
Yellowing of eyes
Dry mouth
Should be avoided at all costs in pregnant and breastfeeding women

Important Warning
This medicine should be used with caution in individuals with kidney disease or impairment of normal kidney function due to the increased risk of severe side effects. Close monitoring of kidney function, necessary dose changes, or replacement with a suitable alternative may be required based on the medical history and health status of the patient.
The usage of this drug may cause symptoms such as tiredness, impaired judgement, impaired body movements, and so on in some people. As a result, it is advised that you avoid undertaking any activities that demand high mental awareness while taking this medication, such as driving a car or operating heavy machinery.

The use of this drug in children and adolescents under the age of 16 is not advised.
This drug should not be taken by pregnant women. If you are pregnant and taking this medication, call your doctor immediately.
Because of the considerable risk of harmful effects on the nursing infant, this medicine is not advised for use in breastfeeding women.

Available Brands (list can be updated in future)