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Thiocolchicoside – An Analgesic and Anti-inflammatory

Thiocolchicoside is a semi-synthetic colchicine derivative used as an analgesic and anti-inflammatory.
Muscoril, Thiolax, and Myolax are all examples of thiocolchicoside, a muscle relaxant with anti-inflammatory and analgesic properties. It is a competitive GABAA receptor antagonist, as well as a potent glycine receptor antagonist and a weaker nicotinic acetylcholine receptor antagonist.

* It has strong convulsant properties and should not be used by people who are prone to seizures.

Class of Medicine
Colchicine is a natural anti-inflammatory glycoside derived from the flower seeds of Superba gloriosa. Thiocolchicoside is a semi-synthetic derivative of colchicine. It’s a muscle relaxant with analgesic and anti-inflammatory properties.

Mode of Action

Thiocholchicoside is a muscle relaxant that operates by binding to the GABA-A receptor selectively. It works by stimulating the GABA inhibitory motor pathway, which stops muscle contractions.

This medicine inhibits glycine receptors with the same efficacy as nicotinic acetylcholine receptors and functions as a competitive GABA receptor antagonist. It has strong convulsant properties and should not be used in people who are prone to seizures.

Patients having hysterosalpingography are sedated with this drug in combination with glafenine and meprobamate. It is used to relieve painful muscle spasms. Thiocolchicoside works in reflex, rheumatic, and traumatic contractures as well as contractures with a central aetiology. It also helps with spastic hemiparesis sequelae, Parkinson’s disease, and iatrogenic Parkinson symptoms, such as neurodyslectic syndrome. Acute and chronic lumbar and sciatic pain, cervico-brachial neuralgia, persistent torticollis, and post-traumatic and post-operative pain are some of the additional disorders that may benefit from this medicine.

How should this medicine be used?
Thiocolchicoside is a muscle relaxant used to treat back pain and other aches caused by diseases of the vertebral column or spinal cord, as well as to relieve pain following surgery. This drug works by interacting with particular receptors in the brain and spinal cord.

The highest suggested oral dose is 8 mg per 12 hours, with a maximum treatment period of 7 days. The highest dose taken intramuscularly (IM) is 4 mg every 12 hours for a maximum of 5 days 14. A study was conducted on the hepatotoxic potential of thiocolchicoside in addition to the aforesaid toxicity.

Common Side Effects
Skin rash
Swelling of face
Yellowing of skin
Yellowing of eyes
Dry mouth
Should be avoided at all costs in pregnant and breastfeeding women

Important Warning
This medicine should be used with caution in individuals with kidney disease or impairment of normal kidney function due to the increased risk of severe side effects. Close monitoring of kidney function, necessary dose changes, or replacement with a suitable alternative may be required based on the medical history and health status of the patient.
The usage of this drug may cause symptoms such as tiredness, impaired judgement, impaired body movements, and so on in some people. As a result, it is advised that you avoid undertaking any activities that demand high mental awareness while taking this medication, such as driving a car or operating heavy machinery.

The use of this drug in children and adolescents under the age of 16 is not advised.
This drug should not be taken by pregnant women. If you are pregnant and taking this medication, call your doctor immediately.
Because of the considerable risk of harmful effects on the nursing infant, this medicine is not advised for use in breastfeeding women.

Available Brands (list can be updated in future)


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Omeprazole | A Proton Pump Inhibitor | PPI

Omeprazole (Risek, Omega, Ruling, Losec) is a drug that lowers the amount of acid produced in the stomach. Stomach acid aids in the digestion of proteins, but too much can create problems such as ulcers and heartburn.

Class of Medicine
Omeprazole belongs to the class of medicine called proton pump inhibitors (PPIs).

Mode of Action
Let’s have a look at the causes of acid-related illnesses. As we all know, the stomach produces acidic fluid that helps with digestion, nutritional absorption, and sterilization of microorganisms found in our food.

While useful, the acidic fluid produced by our stomach can be harmful to the gastrointestinal system, which is why the human body has developed a number of defense mechanisms.

Excessive acid production, on the other hand, might overwhelm our defensive mechanisms, resulting in damage, unpleasant symptoms, and even disease.

PPIs, such as omeprazole, work by inhibiting the enzyme hydrogen-potassium ATPase, which elevates acid levels in the stomach. Omeprazole can help cure ulcers and heartburn by lowering the production of acid in the stomach.

How should this medicine be used?
The way you take omeprazole is determined by why you’re taking it. Omeprazole is usually taken once a day, in the morning, and can be taken with or without meals. In some cases, your doctor may advise you to take omeprazole twice daily, which you should do once in the morning and once at night.

Depending on the ailment being treated, different omeprazole dosages are recommended:

Common omeprazole dosages for dyspepsia are 10-20 mg per day.

Common omeprazole dosages for acid reflux and heartburn are 20-40 mg per day.

Common omeprazole dosages for stomach ulcers are 20-40 mg per day.

In some circumstances, your doctor may advise you to start taking omeprazole at a larger dose for a few weeks before gradually decreasing it. Alternatively, you could start taking omeprazole twice a day and gradually reduce to once a day after a few weeks.

Common Side Effects
Omeprazole use may cause common side effects like:

  • Headache
  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Gas
  • Fever (in children)
  • Respiratory system symptoms (in children)

Some of the negative effects may be serious but very rare.
Rashes, hives, itching, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
Difficulty breathing or swallowing, hoarseness
Irregular, fast, or pounding heartbeat
Excessive tiredness, dizziness, lightheadedness, muscle spasms, cramps, or weakness
Uncontrollable shaking of a part of the body
Severe diarrhea with watery stools
Bone fracture of the hip, wrist or spine
Vitamin B-12 and magnesium deficiency

Available Brands (list can be updated in future)
Most common brands available in the market are as under
Risek (Getz)
Omega (Ferozsons)
Ruling (HIGH-Q)
Maag (Webros)
Omsta (Highnoon)
Protole (Global)
Opepzole (Global)