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Azithromycin | a Macrolide Antibiotic
| Introduction | Azithromycin available under brand names of Azomax, Macrobac, Azitma, Zetro and more, is a macrolide antibiotic with a long half-life and a high level of tissue penetration. It is primarily used to treat respiratory, enteric, and genitourinary infections, but it can also be used to treat some sexually transmitted and enteric infections in place of other macrolides. It has a similar structure to erythromycin 2. |
| Class of Medicine | Azithromycin is a type of antibiotic known as a macrolide antibiotic. It works by either killing or preventing the growth of bacteria. This medication, however, will not help with colds, flu, or other virus infections. |
| Mode of Action | Bacteria require a specific process of protein synthesis, which is enabled by ribosomal proteins, in order to replicate. Azithromycin binds to the bacterial 50S ribosomal subunit’s 23S rRNA. It inhibits protein synthesis in bacteria by inhibiting the transpeptidation/translocation step as well as the assembly of the 50S ribosomal subunit. Labeling As a result, various bacterial infections are controlled. Label number seven. The high affinity of macrolides for bacterial ribosomes, including azithromycin, is consistent with their broad spectrum antibacterial activity. Azithromycin is highly stable at low pH, giving it a longer serum half-life and higher tissue concentrations than erythromycin. |
| Medical Uses | Azithromycin should only be used to treat or prevent infections caused by susceptible bacteria, in order to prevent the development of antimicrobial resistance and maintain the efficacy of azithromycin Label. Azithromycin is used to treat patients who have mild to moderate infections caused by susceptible strains of the microorganisms listed in the specific conditions below. Dosages, duration of therapy, and considerations for different patient populations may differ between these infections. |
| Avaiability & Usage | Pneumonia in the Community Indicated for the treatment of community-acquired pneumonia caused by Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in patients who can take oral antibiotics.Day 1: 500 mg PO x 1 dose, followed by 250 mg PO then OD on 2-5 DaysTonsillitis or Pharyngitis Indicated as an alternative therapy for Streptococcus pyogenes-caused pharyngitis/tonsillitis in patients who are unable to receive first-line therapy.Day 1: 500 mg PO x 1 dose, followed by 250 mg PO then OD 2-5 Days. Skin/skin structure that is uncomplicated Day 1: 500 mg PO x 1 dose, followed by 250 mg PO then Daily on Days 2-5. Exacerbations of chronic obstructive pulmonary disease caused by acute bacterial exacerbations OR 500 mg PO qDay for 3 days Alternatively, on Day 1, take 500 mg PO x 1 dose, followed by 250 mg PO qDay on Days 2-5. Bacterial sinusitis, acute 500 mg PO Daily for three days Chancroid Indicated for the treatment of genital ulcer disease in men caused by Haemophilus ducreyi (chancroid) The efficacy of chancroid treatment in women has not been established. 1 dose of 1000 mg PO Urethritis and Cervicitis caused by nongonococcal or gonococcal bacteria 1 dose of 1000 mg PO Inflammatory Pelvic Disease |
| Side Effects | These common side effects of azithromycin happen in more than 1 in 100 people. There are things you can do to help cope with them: Feeling sick (nausea) Serious side effects Call your doctor right way if: You have a faster or irregular heartbeat (arrhythmia) |
| Important Warning | A word about the dangers of liver toxicity: Because azithromycin is primarily eliminated by the liver, caution should be exercised when administering azithromycin to patients with impaired hepatic function. A word about possible renal toxicity: |
| Available Brands | Azomax Macrobac Azitma Zetro |
